Intended to Deter I.V. Injection of Opioids Extracted from Dissolved Tablets

Drug abusers may dissolve currently marketed tablets or capsules containing abused drugs in water, alcohol, or other common solvents, filter the dissolved solution, and then inject the resulting fluid intravenously to obtain euphoric effects. In product candidates utilizing Aversion® Technology, extracting the active ingredient using generally available solvents, including water or alcohol, into a volume and form suitable for intravenous injection, converts the tablet into a viscous gel mixture and traps the active ingredient in the gel. Additionally, it is not possible, without difficulty, to draw this viscous gel through a needle into a syringe for I.V. injection. We believe that this gel forming feature will limit or impede the ability of prospective I.V. drug abusers from extracting and injecting opioid active ingredients from product candidates developed utilizing Aversion Technology®.