Intentional Swallowing

Intended to Deter Swallowing Excess Quantities of Tablets

Some Aversion® Technology opioid product candidates may also include niacin, an active ingredient in vitamins, cholesterol reducers and nutritional supplements, in amounts believed to be well tolerated when our product candidates are administered at recommended doses.  Niacin has a well established safety profile in long term administration at doses far exceeding the amounts in each product candidate utilizing Aversion® Technology. Prospective drug abusers may swallow excess quantities of tablets beyond the amount intended for analgesia to induce euphoria.  Aversion® Technology products are intended to induce temporary dysphoric effects as increasing numbers of tablets are swallowed above the recommended dose.  We believe that should a person swallow excess quantities of tablets utilizing Aversion® Technology they will experience disliking effects as a result of the increasing dose of niacin.  We believe the niacin induced disliking effects at escalating doses will not prevent, but are expected to deter, swallowing excess quantities of Aversion® Technology product candidates.